Which musculoskeletal disorder is characterized by pain at the base of the thumbs?

De Quervain's Disease is characterized by pain at the base of the thumbs due to inflammation of the tendons surrounding the thumb, specifically those that control thumb movement. This condition primarily affects the extensor pollicis brevis and abductor pollicis longus tendons as they pass through a sheath at the wrist near the base of the thumb. The pain may worsen with thumb movement or gripping activities, making it particularly relevant in jobs or activities that require repetitive motions or sustained use of the hands.

Understanding De Quervain's Disease is essential for recognizing its symptoms and risk factors, especially in occupational settings where ergonomic considerations are vital for injury prevention. Proper ergonomic practices can help reduce the risk of developing this condition and are an important part of overall workplace health and safety.